Comparison of S-1 combined with docetaxel and FOLFOX4 in the treatment of advanced gastic carcinoma

Objective To compare the curative efficacy and safety of the combination of S-1 and docetaxel and FOLFOX4 in the treatment of patients with advanced gastic carcinoma.Methods Seventy-five patients with advanced gastric carcinoma were randomly divided into two groups.Experimental group(37 cases) were treated with the combination of S-1 capsule and docetaxel,one treatment cycle covered 3 weeks.Control group were treated with FOLFOX4 therapy,14 days as a cycle.The efficacy and toxicity were evaluated after 2 cycles.Results The overall effective rate of experimental group and control group was 56.76％ and 47.37％ respectively.There was no significant difference between the two groups (P ＞ 0.05).The main adverse reactions included myelo-depression,nausea,vomiting and diarrhea.Conclusions Two groups have similar effects in the treatment of advanced gastric carcinoma,and the toxicity of the regiment of S-1 combined with docetaxel is mild and tolerable. Key words: Advanced gastric carcinoma;  S-l;  Docetaxel;  FOLFOX4