Influence of Different Fat Emulsion-Based Intravenous Formulations on the Pharmacokinetics and Pharmacodynamics of Propofol

Eugène H. Cox,Catherijne A. J. Knibbe,Victorine S. Koster,M. W. E. Langemeijer,Erica Tukker,Rogier Lange,Paul F. M. Kuks,Han J. M. Langemeijer,Loraine Lie-A-Huen,Meindert Danhof

Influence of Different Fat Emulsion-Based Intravenous Formulations on the Pharmacokinetics and Pharmacodynamics of Propofol

1998

Eugène H. Cox
Catherijne A. J. Knibbe
Victorine S. Koster
M. W. E. Langemeijer
Erica Tukker
Rogier Lange
Paul F. M. Kuks
Han J. M. Langemeijer
Loraine Lie-A-Huen
Meindert Danhof

Purpose. The influence of different intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol was investigated using the effect on the EEG (11.5-30 Hz) as pharmacodynamic endpoint.

Keywords:

Pharmacodynamics
Emulsion
Dosage form
Propofol
Pharmacology
Anesthesia
Chemistry
Biological activity
Pharmacokinetics
pharmacology toxicology
fat emulsion

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