Mutations in MurE, the essential UDP- N -acetylmuramoylalanyl- d -glutamate 2,6-diaminopimelate ligase of Corynebacterium glutamicum : effect on l -lysine formation and analysis of systemic consequences

Objectives To explore systemic effects of mutations in the UDP-N-acetylmuramoylalanyl-d-glutamate 2,6-diaminopimelate ligase (MurE) of Corynebacterium glutamicum, that leads to extracellular l-lysine accumulation by this bacterium.