Perfusion of the uterine junctional zone in nulliparous and primiparous women assessed by DCE-MRI as a function of menstrual cycle and hormonal contraception.
2017
Abstract Purpose To evaluate the perfusion parameters of inner and outer myometrium in healthy nulliparous and primiparous women who are and who are not currently using hormonal contraceptives by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Material and methods We performed pelvic 1.5 T DCE-MRI on 98 women: 18 nulliparous non-users, 30 nulliparous users, 12 primiparous non-users and 38 primiparous users of hormonal contraception (mean age respectively 26.4, 25.8, 30.23 and 28.18 years). The nulliparous non-users underwent DCE-MRI investigations during their follicular, ovulatory and luteal phase. Perfusion parameters (iAUC/volume, Ktrans, Kep and Ve) were assessed in the anterior and posterior junctional zone (JZ), outer myometrium and cervix. Results In nulliparous non-users, the mean Ktrans and iAUC/volume showed a decrease from follicular to luteal phase (0.82 vs 0.55 min − 1 for Ktrans, p = 0/027 and 1.28 vs 0.68 for iAUC/volume, p p = 0.050) and higher Kep ( p = 0.012), in nulliparous non-users, lower Ktrans in nulliparous users ( p p = 0.012) than the anterior outer myometrium. Ktrans at the anterior and posterior JZ wall in nulliparous users was lower than in non-users ( p = 0.001 and p = 0.013) and Ve at the anterior JZ wall in primiparous users was lower than in non-users ( p = 0.044). Conclusion This study provides data on normal perfusion parameters of inner and outer myometrium, which may be potentially useful in assisted reproductive therapy.
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