Polymorphism and CDC25A Gene Expression in Pancreatic Cancer

Background and Aim: The aim of this study is to determine the relationship between CDC25A gene polymorphism and pancreatic cancer via determining CDC25A gene expression and polymorphisms of tumor tissues of pancreatic cancer cases Additionally, it is aimed to prove the possible relationship between cancer development and the gene expression level with determining CDC25A gene expression levels in tumor tissue and normal tissue Materials and Methods: patients patients with pancreatic cancer who received surgery n 2 and patients with pancreatic cancer who are in follow up n  and  healthy volunteers not having any known chronic disease and first degree relatives having cancer were included in this study as a control group  Results: SerPhee polymorphisms in CDC25A gene of pancreatic cancer and control groups were compared according to C/C, C/T, T/T genotype freuencies and allele freuencies of C and T and no statistically significant difference was detected between two groups p5 RS5 polymorphisms in CDC25A gene of pancreatic cancer and control groups were compared with respect to C/C, C/G, G/G genotype freuencies and allele freuencies of C and G and there was no significant difference between them statistically p5 There were no differences in CDC25A gene expression between control group and pancreatic cancer group p5 Conclusion: In the light of the data obtained, any significant relationship at the CDC25A gene polymorphism and expression in pancreatic cancer was not detected All in all, pancreatic cancer is a disease with high mortality and the place of genetics in the etiology of cancer is indisputable Therefore, we think the polymorphism and expression studies should be continued  ( Sakarya Med J 2016, 6(1):7-13 ) Keywords: Pancreatic cancer, CDC25A, polymorphism, expression