Fluorine in peptides : Coiled coil model systems as tools to evaluate the influence of fluorinated amino acids on structure and stability of peptides

Protein folding, structure, and activity are based on a multitude of molecular interactions, all controlled by the primary structure. As only 20 canonical amino acids are available, the incorporation of non-natural building blocks is a success ul approach in protein engineering. The use of fluorinated amino acids is especia ly promising and has been studied intensively in recent years. This mini review focuses on the application of the coiled coil folding motif to systematically study the impact of fluorine on structure and stability of peptides and proteins.