[Effect of Different Processed Products and Extracts of Morinda officinalis Root on Adjuvant-Induced Arthritis in Rats].

Objective: To study the therapeutic effects of different processed products and extracts of Morinda officinalis root in rat adjuvant-induced arthritis( AA) model,and to explore the possible mechanism. Methods: AA model in SD rats was established,then the arthritic rats were randomly divided into seven groups such as model,Tripterygium Glycosides Tablet( TGT),morinda with xylem,morinda,salt-steamed morinda,licorice-processed morinda,morinda Et OAc extract,morinda n-Bu OH extract,H2 O residue,total polysaccharides and control groups. The paw edema and arthritis indexes were observed,and the contents of tumor necrosis factor-α( TNF-α),interleukin-1β( IL-1β),IL-6,IL-2 and INF-γ in AA rats serum were detected by ELISA. Results: Morinda processed by salt and n-Bu OH extract could reduce paw swelling and levels of TNF-α,IL-1β,IL-6 and INF-γ in AA rats serum,which followed by morinda Et OAc extract. The differences were significant compared with the model group( P 0. 05 or P 0. 01). Conclusion: Salt-steamed morinda and morinda n-Bu OH extract have the best curative effect,followed by morinda Et OAc extract. Reducing TNF-α,IL-1β,IL-6 and INF-γ contents in serum may be the mechanism of drug treatment of rheumatoid arthritis.