Potential use of Ca++ scanning to determine the need for and intensity of lipid-lowering therapy in asymptomatic adults

Deficiencies in traditional cardiovascular risk-factor assessment in asymptomatic individuals have led to the use of electron beam computed tomography (CT) scanning as a screening test for coronary artery disease. This novel approach is based on a secure pathologic foundation: the risk of coronary disease events is proportional to the severity and extent of underlying coronary atherosclerosis, and in middle-aged and elderly adults, calcified plaque is closely related to total plaque. Electron beam CT measures coronary calcium quickly, easily, accurately, and with a high degree of reproducibility. Coronary calcium is three to nine times higher in persons with fatal or nonfatal myocardial infarction than in age-matched controls, and four observational outcomes studies have demonstrated that the electron beam CT-derived coronary calcium score predicts fatal and nonfatal myocardial infarction. In symptomatic persons undergoing cardiac catheterization, electron beam CT is more closely associated with the severity of coronary atherosclerosis than are standard coronary risk factors. Preliminary evidence in asymptomatic persons indicates that the coronary calcium score also predicts coronary disease events more accurately than standard risk factors.