Comparison of D-dimer Level Measured on the Third Day of Hospitalization with Admission D-dimer Level in Predicting In-hospital Mortality in COVID-19 Patients

OBJECTIVE: The present study aimed to compare the value of D-dimer measured on the 3rd day of hospitalization with admission D-dimer level in predicting in-hospital mortality in coronavirus disease 2019 (COVID-19) cases METHOD: In total, 231 patients with COVID-19 disease were included in the study D-dimer levels were estimated using immunoturbidimetric assay with normal range of 0-500 μg/mL In the current research, the primary outcome was the in-hospital mortality RESULTS: In the present research, 39 (16 8%) COVID-19 cases died during the index hospitalization In a multivariable analysis;age, D-dimer (3(rd) day) (OR: 1 00, 95% CI: 1 00-1 00, p<0 001), WBC count, and creatinine were independent predictors of the in-hospital death for COVID-19 cases The ideal value of D-dimer level on the 3(rd) day of hospitalization was 774 μq/mL (area under curve (AUC): 0 903, 95% CI: 0 836-0 968;p<0 01) with sensitivity of 83 2% and specificity of 83 6% It was noted that D-dimer level on the 3(rd) day of hospitalization had a higher sensitivity (83 2% vs 67 6%, respectively) and AUC value than that of D-dimer level on admission (0 903 vs 0 799, respectively) CONCLUSION: The main finding in this investigation was that D-dimer elevation on the 3(rd) of hospitalization is more sensitive predictor of in-hospital mortality than D-dimer elevation on admission in COVID-19 patients Even though further investigations are needed to forecast precise prognosis in patients with COVID-19 disease in terms of D-dimer levels, we believe that D-dimer levels on the 3(rd) day of hospitalization have an enhanced potential to be used as a prognostic marker in routine clinical practice