Clinicopathological features and prognosis of 68 patients with metastatic ovarian tumors from the gastric cancer
2010
Objective To investigate the clinicopathalogical features and prognosis of metastatic ovarian tumors from gastric cancer. Methods Clinical data of 68 patients with metastatic ovarian carcinoma were reviewed retrospectively. Results The median age was 46 years. The majority of these patients was in the premenopausal state (67.6%) and had bilateral ovarian involvement (64.7%).Pathological type was signet-ring cell carcinoma in 52.9% of the cases. Most of them underwent surgical treatment or chemotherapy or both. The median overall survival was 14.1 months, and the median progression-free survival was 6.7 mouths. The survival rates in 1-, 3-and 5-year were 54.8%, 14.9% and 0, respectively. Univariable analysis revealed that resection of gastric cancer, lymphatic metastasis,pathologic type of metastatic ovarian tumor, extent of metastatic lesion, cytoreductive surgery and chemotherapy for metastatic ovarian carcinoma were associated with the prognosis. Multivariable analysis revealed that cytoreductive surgery and extent of metastatic lesion were independent factors. Patients with metastatic lesion confined to the ovaries had a median overall survival of 16.0 months as compared to 8.6 months for those with more extensive metastases(P 2 cm)(P<0.01). Optimal cytoreduction was also associated with a significantly longer median progression-free survival(11.0 months) as compared to suboptimal cytoreduction median progression-free survival (3.1 months)(P<0.01). Conclusions Prognosis of patients with metastatic ovarian carcinoma from gastric cancer is quite poor. Extent of metastatic lesion is an independent factor. Optimal cytoreduction is associated with improved survival.
Key words:
Stomach neoplasms; Neoplasm metastasis,ovarian; Prognosis
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