Condensate derivative aminodihidrotiazina

2009 
A compound represented by formula (I): Formula ** ** or a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein Ring A is a C6-14 aryl group which may have 1 to 3 substituents selected from substituent α group, a heteroaryl group of 5 to 6 members which may have 1 to 3 substituents selected from substituent α group, or a heterocyclic group benzofused 9 to 10 members which may have 1 to 3 substituents selected from substituent α group, L is a single bond, an oxygen atom, a formula -NReCO- (wherein Re is a hydrogen atom or C1-6 alkyl group which may have 1 to 3 substituents selected from substituent group α), a formula -NReSO2- (wherein Re is a hydrogen atom or C1-6 alkyl group which may have 1 to 3 substituents selected from substituent group α), a formula -NRe- (wherein Re is a hydrogen atom or C1-6 alkyl group which may have 1 to 3 substituents selected from Substituent Group α), a C1-6 alkylene group which may have 1 to 3 substituents selected from Substituent Group α, a C2-6 alkenylene group which may have 1 to 3 substituents selected from Substituent Group α, or C2-6 alkynylene group which may have 1 to 3 substituents selected from substituent group α, Ring B is a C3-8 cycloalkyl group which may have 1 to 3 substituents selected from substituent group α, an aryl group of C6 -14 which may have 1 to 3 substituents selected from substituent group α or a heterocyclic group of 5 to 10 members which may have 1 to 3 substituents selected from substituent group α, X is a methylene group which may have 1 to 2 substituents selected substituent group α, Y a single bond, -NRY- (wherein RY is a hydrogen atom, C1-6 alkyl group that may have 1 to 3 substituents selected from substituent group α, or n C1-6 alkyl-carbonyl which may have 1 to 3 substituents selected from Substituent Group α, a carbonyl C6-14 aryl group which may have 1 to 3 substituents selected from Substituent Group α, an alkyl C1-6 alkylsulphonyl which may have 1 to 3 substituents selected from substituent group α, a sulfonyl C6-14 aryl group which may have 1 to 3 substituents selected from substituent group α, an aryl group of 6-14 that may have 1 to 3 substituents selected from substituent group α, or a heterocyclic group of 5 to 10 members that may have 1 to 3 substituents selected from substituent group α) or an oxygen atom, Z is a single bond or a C1-3 alkylene group which may have 1 to 3 substituents selected from substituent group α, R1 and R2 are each independently a hydrogen atom, an alkyl group of C1-6 which may have 1 to 3 substituents selected from substituent group α, carbo-C1-6 alkyl group nile which may have 1 to 3 substituents selected from Substituent Group α, a carbonyl C6-14 aryl group which may have 1 to 3 substituents selected from Substituent Group α, an alkyl C1-6 alkylsulphonyl which may have 1 to 3 substituents substituent group α selected, a C6-14 aryl sulfonyl group which may have 1 to 3 substituents selected from substituent group α, a carbocyclic group of 3 to 10 members that may have 1 to 3 substituents selected from substituent group α, or heterocyclic group of 5 to 10 members which may have 1 to 3 substituents selected from substituent group α, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom, a hydroxy group, an alkyl group of C1- 6 which may have 1 to 3 substituents selected from substituent group α, C1-6 alkoxy group that may have 1 to 3 substituents selected from substituent group α, a carbocyclic group of 3 to 10 members qu and may have 1 to 3 substituents selected from Substituent α group, or a heterocyclic group of 5 to 10 members which may have 1 to 3 substituents selected from Substituent α group [Substituent Group α: a hydrogen atom, a halogen atom, a hydroxy group, a nitro group, a C1-6 alkylthio-group, a C6-14 aryl group, C6-14 aryl oxycarbonyl group, an aryl C6-14 alkylcarbonyl, a cyano group, a cycloalkoxy group C3-8, C3-8 cycloalkyl group, a thio C3-8-cycloalkyl group, a sulfonylamino group (wherein the sulfonylamino group may be substituted with a C1-6 alkyl group), an alkenyl group of C2 -6 I may have 1 to 3 substituents selected from substituent group α, C2-6 alkynyl group that may have 1 to 3 substituents selected from substituent group α, a carbamoyl group which may be substituted with one to two groups C1 -6 a C1-6 alkoxy group which may have 1 to 3 substituents seleccio Substituent Group α, a group Nados C1-6 alkyl which may have 1 to 3 substituents selected from Substituent Group α, and a heterocyclic group of 5 to 10 members which may have 1 to 3 substituents selected from Substituent group α, Substituent Group α: a halogen atom, a cyano group, a hydroxy group, a C1-6 alkoxy group, C1-6 alkyl group, C3-8 cycloalkyl group and an oxo group].
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