Acceleration of graft rejection by pretreatment of the graft donor with recipient cells (donor sensitization)

Abstract Immunization of mice with enzyme-treated allogeneic tissue resulted in accelerated rejections when skin from the immunized mice was transplanted to recipients syngeneic with the tissue donors. This accelerated rejection was restricted to the recipient whose tissue was used to sensitize the donor. Further, skin grafts from one parental strain sensitized to the other parental strain usually underwent a partial rejection when placed on the F 1 hybrid. It is suggested that under these experimental conditions the transplanted skin appeared to have an active role in the rejection process.