Omega-3 Fatty Acids and HDL. How Do They Work in the Prevention of Cardiovascular Disease?
2012
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) from marine origin have been strongly associated with cardiovascular
protection, even at low doses (< 1g/d). Despite the research performed in this promising area, basic aspects,
such as the ideal doses and the mechanisms by which ω-3 PUFAs act, are not precisely defined. The best known biological
property of ω-3 PUFAs is their hypotriglyceridemic effect, but other cardioprotective actions, such as reduction of arrhythmia
susceptibility, antithrombotic, antiinflammatory and antioxidant effects, improvement of endothelial function,
and delayed atherosclerosis development have received an increased interest in recent years. Some of these actions are
also ascribable to high-density lipoproteins (HDL). Abundant epidemiological evidence links increasing HDL-cholesterol
concentrations to cardiovascular protection. Recently, the protein cargo (proteome) of HDL particles has been attributed a
key role in their functionality. In this review, we summarize the main effects of ω-3 PUFAs on HDL-cholesterol, HDL
subfractions, and its main proteins, apolipoproteins (apo) AI and AII. The shared cardioprotective actions of ω-3 PUFAs
and HDL are reviewed as well.
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