Ultrastructure of Antibody-forming Cells

THE method of Jerne and Nordin for demonstrating individual antibody-forming lymphoid cells has been utilized to obtain quantitative information about the cellular changes during antibody formation1, to indicate transplantation immunity2 and to demonstrate antibody-forming cells in ‘tolerant’ animals3. Recently, this method has been combined with autoradiography to investigate the kinetics of antibody formation4. In the present studies the plaque method has been used to identify for study by electron microscopy individual cells which have released antibody.