Poster 118 Prolonged Treatment of Paroxysmal Sympathetic Hyperactivity Limits Functional Gains: A Case Report

by admission and discharge functional independence measure (FIM). Clinical characteristics including age, sex, race, marital status, stroke risk factors, stroke site, and discharge destination were recorded. The association between serum BDNF level and stroke functional outcomes was assessed using Pearson’s correlation analysis. Results or Clinical Course: The mean serum BDNF level was 22.60� 9.87ng/ml (range, 5.22-44.83ng/ml). Pearson’s correlation analysis showed that the lower serum BDNF level was associated with less marital family support (r¼0.316, P¼.047), lower FIM motor subscore on admission (r¼0.338, P¼.033) and discharge (r¼0.355, P¼.025) and lower total FIM score on discharge (r¼0.363, P¼.021). Stroke patients with lower serum BDNF level were more likely to be discharged to skilled nursing facility (r¼-0.407, P¼.009). Conclusion: Serum BDNF level was associated with functional outcomes as measured by FIM and discharge destination within 2 month of the onset of stroke. BDNF may serve as a prognostic biomarker for functional recovery and may be used as a surrogate marker to evaluate the responsiveness to targeted neurorestorative therapies. Larger scale studies are warranted to confirm these results.