Predicting Outcomes of Oral Food Challenges by Using the Allergen-Specific IgE-Total IgE Ratio

RA Gupta, CH Lau, RG Hamilton, A Donnell, KK Newhall. J Allergy Clin Immunol Pract. 2014;2(3):300–305 To examine the accuracy of the ratio of serum immunoglobulin (sIgE) to total immunoglobulin E (tIgE; “Ratio”) in predicting the outcome of oral food challenges. The study population was derived from an allergy outpatient clinic in Chicago, Illinois, from 2009 to 2013. The study included children aged 11 months to 18 years (median 4.0 years) with history of food allergy to milk, egg, soy, peanut, tree nuts, shellfish, or seeds, who underwent oral food challenges (OFC) to those foods and for whom food-specific (sIgE) and tIgE values were obtained. This was a retrospective chart review. The Ratio was calculated …