rs895819 in microRNA-27a increase stomach neoplasms risk in China: A meta-analysis

Abstract Background Across the globe, gastric cancer is a significant public health problem. This meta-analysis was conducted to investigate the association of microRNA-27a (miRNA-27a) rs895819 with gastric cancer risk. Methods The search of databases updated on October 10, 2018 included Pubmed, Embase, Cochrane Library and Web of science. Odds ratio (ORs) and 95% confidence interval (CIs) were calculated to assess the risk of tumor. Results Overall meta-analysis suggested the miRNA-27a rs895819 was not related to the gastric carcinogenesis among all model including allele contrast (G vs A, pooled OR: 1.096, 95% CI: 0.962–1.249, P  = 0.196), codominant model (GG vs AA, pooled OR: 1.124, 95% CI: 0.794–1.592, P  = 0.590; AG vs AA, pooled OR: 1.101, 95% CI: 0.966–1.217, P  = 0.060), dominant model (AG + GG vs AA, pooled OR: 1.123, 95% CI: 0.964–1.307, P  = 0.136) and recessive model (GG vs AG + AA, pooled OR: 0.927, 95% CI: 0.673–1.278, P  = 0.644). Interestingly, among different ethnicity group, significant relation between rs895819 and gastric cancer was observed in co-dominant model among Chinese population (AG vs AA, pooled OR: 1.158, 95% CI: 1.038–1.291, P  = 0.008) but not some regions of European population (AG vs AA, pooled OR: 0.852, 95% CI: 0.632–1.148, P  = 0.179). Conclusions Our results find that rs895819 contributed to occurrence of gastric cancer in co-dominant model in Chinese population.