Recombinant human platelet-derived growth factor-BB in human alveolar ridge augmentation: A review of the literature

PURPOSE: The objective of this study was to review the available literature regarding the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in human alveolar ridge augmentation and to assess its effectiveness for this specific use. MATERIALS AND METHODS: Three electronic searches of the MEDLINE database were performed. RESULTS: This review noted a wide range of study protocols, carrier systems, study periods, and outcome measures. CONCLUSION: Within the limits of this literature review, the use of rhPDGF-BB and bone regeneration/ridge augmentation led to greater clinical attachment level gain and bone regeneration prior to implant placement. More controlled clinical studies are needed to establish the effectiveness of rhPDGF-BB in alveolar ridge augmentation.