A General Route to 1,5-Disubstituted 1,2,3-Triazoles with Alkyl/Alkyl, Alkyl/Aryl, Aryl/Aryl Combinations: A Metal-Free, Regioselective, One-Pot Three Component Approach.

An experimentally simple one-pot reaction, affording 1,5-disubstituted 1H-1,2,3-triazoles in good to excellent yields by combining vinyl sulfones, sodium azide and alkyl bromides, -tosylates, -mesylates or aryl amines, -iodides is reported. The organic azides, generated in situ react with vinyl sulfones in a regioselective fashion in the absence of metal ions. Unlike many of the recently reported strategies, this method is capable of generating alkyl/alkyl, alkyl/aryl and aryl/aryl containing 1,5-disubstituted 1,2,3-triazoles under simple reaction conditions.