Felodipine film-controlled slow-release pellet capsule

2012 
The invention relates to a felodipine film-controlled slow-release pellet capsule. A slow-release film of the felodipine film-controlled slow-release pellet utilizes Eurdragit RL 30D as a film-formation material. A pellet core of the felodipine film-controlled slow-release pellet contains sodium carboxymethyl starch having high expansibility, and also contains pharmaceutically acceptable common excipients for the slow-release pellet, wherein preferably, the excipients comprise microcrystalline cellulose and lactose as fillers and polyoxyethylene hydrogenated castor oil RH40 as a solubilizer, and the pellet core comprises 5 to 20wt% of sodium carboxymethyl starch. The slow-release film comprises Eurdragit RL 30D, triethyl citrate as a plasticizer and talcum powder as an antiplastering aid, wherein preferably, a ratio of Eurdragit RL 30D to triethyl citrate to talcum powder is 30: 3: 4 and a film weight increasing ratio is in a range of 20 to 36%. The felodipine film-controlled slow-release pellet comprises the pellet core containing sodium carboxymethyl starch having high water expansibility and thus after absorbing water, the felodipine film-controlled slow-release pellet expands so that the slow-release film is stretched; the thickness of the slow-release film is reduced; the water-permeable micropore size is increased; and permeability is improved and the permeability reduction caused by film aging is counteracted. Therefore, in middle and later stages, the felodipine film-controlled slow-release pellet release rate is basically constant; in the last stage, residues are less; and stable release performances can be kept in the period of validity.
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