Side effects of tuberculosis treatment with fixed-dose combinations

Introduction: Anti-tubercular treatment is often well tolerated. However, side effects (SE) drugs can cause significant morbidity, and compromise treatment regimens for tuberculosis (TB) Aim: To explore the therapeutic effect and safety of Fixed-Dose Combinations (FDCs) on tuberculosis and to study the correlation between the appearance of SE with the age, comorbidities and the prescribed dose. Methods: Retrospective study including 50 patients with active tuberculosis treated in our department with FDCs between 2014 and 2015. Results: The group consisted of 20 men and 30 women with an average age of 44years The Symptoms were dominated by alteration of the general state (33%), cough (29%), night sweats (23%) and hemoptysis (10%).SE were reported in 83% of patients. Major side effects were reported in 18%: Dress syndrome (2 cases), hepatic cytolysis (3 cases) and cutaneous reactions (4 cases). Minor side effects were reported in 65%: hepatotoxicity, Hyperuricemia, Peripheral neuropathy and Nausea.The mean time for the appearance of the side effects was 15 days. The molecule responsible was: (Piazoline (4 cases); Rifadine (3 cases) and Ethambutol (1 case). A correlation was found between the occurrence of side effects, the age and the diabetes comorbidities. Conclusion: This work describes the adverse events of different antibiotic medications so that, on an individual basis they can be anticipated and appropriately managed.