P-0066FREQUENCY OF PATHOLOGICAL COMPLETE RESPONSE WITH NEO-ADJUVANT CHEMORADIOTHERAPY IN LOCALLY ADVANCED ESOPHAGEAL CANCER

Background: Neoadjuvant chemoradiotherapy followed by esophagectomy has become the standard of care for patients with locally advanced esophageal cancer. The achievement of a pathological complete response is associated with an improved survival. This report analyzes our experience with this treatment approach. Methods: With a median age of 52 years (range 20 - 74), we retrospectively analyzed 61 patients (males 58%, females 42%) between 2003 to 2012 with pathologically confirmed esophageal cancer, treated with neo-adjuvant chemoradiotherapy followed by esophagectomy. Pre-treatment AJCC stage; stage I 6%, stage II 46% and stage III 48% of the patients respectively. Site distribution; upper thoracic 2%, middle thoracic 24%, lower thoracic 62% and gastroesophageal junction tumour in 12% of the patients. Mean tumour length was 5.8 cm (range 2 - 11). Histological sub-types include; squamous cell carcinoma 80% and adenocarcinoma 20% of the patients. 78% of the