Frovatriptan succinate controlled-release granule and preparation method thereof

2015 
The invention discloses a frovatriptan succinate controlled-release granule, which is prepared by controlled-release coating an inner core which is prepared from frovatriptan succinate by virtue of an inclusion technology. The invention also discloses a preparation method of the frovatriptan succinate controlled-release granule. Compared with the prior art, the controlled-release granule disclosed by the invention can slowly release drugs at a constant speed in a specified release medium, so that the release degree and the bioavailability of the frovatriptan succinate are effectively improved; the controlled-release granule can achieve rapid release to cause efficacy in the initial stage of medication and can realize slow release at the constant speed in the later stage so as to keep a normal blood concentration, therefore the efficacy is kept for a long time without the generation of toxic or side effects or intoxication due to drug accumulation, the curative effect is improved and the controlled-release is safe and rapid. Meanwhile, the preparation method of the invention is applicable to expanded production.
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