Urea Transport Across Peritoneal Membrane In Vitro: Influence of Protamine Sulfate, Glyoxal, and Methylglyoxal

Four separateseries of experiments were conducted. In the firstexperiment, transperitoneal transfer of urea (20mg/dL) in control conditions over 120 minutes wasanalyzed. In the subsequent three experiments,transport parameters were analyzed before (15 –60 minutes) and after (75 – 120 minutes) the additionof chemical factors (protamine sulfate 5 mg/dL, gly-oxal 10 mg/dL, methylglyoxal 1 mg/dL) on the me-sothelial side of the peritoneal membrane.Stability of urea transport was observed in thecontrol series (120 minutes). The mean diffusive per-meability coefficients (