Long Term Effects of Nightly Dexamethasone Administration in Patients with Polycystic Ovarian Disease

The long term effects of nightly dexamethasone administration on basal levels and diurnal fluctuations of circulating gonadotropins, androgens, and cortisol were studied by frequent sampling in four women with polycystic ovarian disease and a similar number of normal women. Basal LH, testosterone, and androstenedione levels were elevated in the patients with polycystic ovarian disease. There were significant diurnal variations of all steroids measured in both groups, with the exception of androstenedione and androstenediol in the polycystic ovarian disease and control subjects, respectively. Nightly dexamethasone administration for 1 month resulted in marked suppression of dehydroepiandrosterone, androstenediol, and cortisol. For testosterone the mean percent decreases of the 24-h transverse means were 15‰ and 46‰ for the polycystic ovarian disease and normal subjects, respectively. For androstenedione the mean percent decreases were only 7‰ and 20‰, respectively. The diurnal variation of all steroids dis...