Protein Expression Arrays for Proteomics

1. IntroductionOverview: Array-Based Proteomics The key advantage to array-based methods for protein study is the parallel analysis of samples in a high-throughput fashion. Similar to the DNA microarray, this approach requires miniaturization technologies, high sample throughput, and automation. Arraybased methods for protein analysis afford a high-throughput format by which to screen protein‐protein, protein‐DNA, and protein‐small molecule interactions and provides important functional information for newly identified genes that are derived from genome projects. Protein arrays hold the potential to identify these interactions as well as provide a means for differential expression and protein profiling between different cell types.