Individualizing the WHO HIV and infant feeding guidelines: optimal breastfeeding duration to maximize infant HIV-free survival

2014 
Objectives: To determine how infant feeding recommendations can maximize HIVfree survival (HFS) among HIV-exposed, uninfected African infants, balancing risks of breast milk-associated HIV infection with setting-specific risks of illness and death associated with replacement feeding. Design: Validated mathematical model of HIV-exposed, uninfected infants, with published data from Africa. Methods: We projected 24-month HFS using combinations of: maternal CD4 þ , antiretroviral drug availability, and relative risk of mortality among replacement-fed compared to breastfed infants (‘RR-RF’, range 1.0‐6.0). For each combination, we identified the ‘optimal’ breastfeeding duration (0‐24months)maximizing HFS.WecomparedHFS under an‘individualized’approach, basedontheaboveparameters,to the WHO ‘public health approach’ (12 months breastfeeding for all HIV-infected women). Results: Projected HFS was 65‐93%. When the value of RR-RF is 1.0, replacement feeding from birth maximized HFS. At a commonly reported RR-RF value (2.0), optimal breastfeeding duration was 3‐12 months, depending on maternal CD4 þ and antiretroviral drug availability. As the value of RR-RF increased, optimal breastfeeding duration increased. Compared to the public health approach, an individualized approach improved absolute HFS by less than 1% if RR-RF value was 2.0‐4.0, by 3% if RR-RF value was 1.0 or 6.0, and by greater amounts if access to antiretroviral drugs was limited. Conclusion: Tailoring breastfeeding duration to maternal CD4 þ , antiretroviral drug availability,andlocalreplacementfeedingsafetycanoptimizeHFSamongHIV-exposed infants. An individualized approach leads to moderate gains in HFS, but only when mortality risks from replacement feeding are very low or very high, or antiretroviral drug availability is limited. The WHO public health approach is beneficial in most resourcelimited settings.
    • Correction
    • Source
    • Cite
    • Save
    • Machine Reading By IdeaReader
    54
    References
    5
    Citations
    NaN
    KQI
    []