For enhancing the expression of hsp47 regulated retinoid liposome

Describes a pharmaceutical composition comprising a double stranded nucleic acid molecule, the double-stranded molecule comprising a sense strand and an antisense strand, wherein said sense strand and an antisense strand selected from the group described in SERPINH1_2 (SEQ ID NO: 60 and 127 ), SERPINH1_45a (SEQ ID NO: 98 and 165), and SERPINH1_51 (SEQ ID NO: 101 and 168) oligonucleotides comprising a pharmaceutical carrier and describes retinoids and lipid vehicles, and the use of these drugs a method of treating compositions hsp47-related diseases (including fibrosis).