Closed Loop Stimulation and Evaluation of the Effect of the Autonomic Nervous System Using Heart Rate Variability

Summary It is well-known that the sinus node supports an adequate heart rate in response to mental, emotional, and physical stress. A heart rate variability analysis is based on small variations in heart rate caused by sympathetic and parasympathetic activities. A sensor system called Closed Loop Stimulation is believed to be capable of restoring normal sinus node function. This study evaluates the autonomic sensitivity of CLS to a group of pacemaker patients as well as its effect on the autonomic nervous system, according to the heart rate variability, as compared with healthy individuals. A total of 58 patients with an Inos 2+ CLS pacemaker were included in the study along with 37 individuals without a pacemaker. All patients were connected to a 24-hour Holter, and the heart rate variability time and frequency domain data were collected, indicating a close response between CLS patients and healthy individuals.