Cancer control via glucose and glutamine deprivation.

Dear Sir, Polet and Feron [1] elucidate inter alia pharmacological interventions, which affect the glucose, glutamine and lactate pathways. These are important due to their putative anticancer effects. Recapitulating their therapeutic effect is unfortunately difficult by only cytotoxic means [2] due to, among others, the ‘innocent bystander effect’ [3]. Recent evidence, however, suggests that control of highly glycolytic cancer may be simpler than expected.