Tomato Ve disease resistanc surface-like receptors

In tomato, Ve is implicated in race-specific resistance to infection by nL Verticillium species causing crop disease. Characterization of the Ve re locus involved positional cloning and isolation of two closely in linked inverted genes. Expression of individual Ve genes in susceptible potato plants conferred resistance to an aggressive race 1 VI isolate of Verticillium albo-atrum. The deduced primary structure dc of Vel and Ve2 included a hydrophobic N-terminal signal peptide, id leucine-rich repeats containing 28 or 35 potential glycosylation dc sites, a hydrophobic membrane-spanning domain, and a C-terminal 0.' domain with the mammalian E/DXXXLO or YXX4 endocytosis us signals (O is an amino acid with a hydrophobic side chain). A leucine ar zipper-like sequence occurs in the hydrophobic N-terminal signal to peptide of Vel and a Pro-Glu-Ser-Thr (PEST)-like sequence resides in the C-terminal domain of Ve2. These structures suggest that the re Ve genes encode a class of cell-surface glycoproteins with receptor- be mediated endocytosis-like signals and leucine zipper or PEST Sin sequences. th pr