Candidate drug therapies for molecularly defined subgroups of esophageal cancer identified from high-throughput drug screening.

4039 Background: There is a pressing clinical requirement to identify novel treatment strategies for oesophageal cancers, especially considering the rising incidence and poor patient prognosis. The use of high-throughput small molecule drug screens has the potential to identify therapies not previously acknowledged to be efficacious for individual cancer types. Methods: To identify effective drug therapies for molecularly defined subgroups of patients with oesophageal cancer, high-throughput drug screening was undertaken in 17 oesophageal cancer cell line models using a small molecule library incorporating 78 drugs. Genomic profiles regarding gene mutation and copy number variation for each of the oesophageal cell line models used in the drug screen were obtained from publically available data repositories (Cancer Cell Line Encyclopedia and COSMIC cell line project). Results: Broad spectrum sensitivity across the oesophageal cell line models was observed for targeted agents including PF03758309 (PAK4 inhi...