Allograft infiltration and meningoencephalitis by sars-cov-2 in a pancreas-kidney transplant recipient

Introduction: COVID-19 primarily affects epithelia of the upper and lower respiratory tract Thus, impairment of kidney function has been primarily attributed to secondary effects like cytokine release or fluid balance disturbances so far Methods: We provide evidence that SARS-CoV-2 can directly infiltrate a kidney allograft Results: A 69-year old male pancreas-kidney transplant recipient presented to our hospital with COVID-19 pneumonia and impaired pancreas and kidney allograft function Kidney biopsy was performed showing tubular damage and an interstitial mononuclear cell infiltrate RT-PCR from the biopsy specimen was positive for SARS-CoV-2, while being negative in a peripheral blood sample Subsequently, he suffered from two convulsive seizures Magnetic resonance tomography suggested meningoencephalitis, which was confirmed by SARS-CoV-2 RNA transcripts in the cerebrospinal fluid Conclusion: The present case demonstrates that SARS-CoV-2 can infiltrate diverse organs The patient suffered from COVID-19 pneumonia, meningoencephalitis and nephritis SARS-CoV-2 binds to its target cells through angiotensin-converting enzyme 2, which is expressed in a broad variety of tissues including the lung, brain and kidney SARS-CoV-2 thereby shares features with other human coronaviruses including SARS-CoV that were identified as pathogens beyond the respiratory tract as well The present case should provide awareness that extrapulmonary symptoms in COVID-19 may be attributable to viral infiltration of diverse organs