A HIGH bacteria and their application in fermentation epothilone of epothilone

Producing Strains and Its Application to an epothilone in an epothilone in the fermentation, classified named cellulolytic myxobacteria (Sporangium cellulosum) YU-970, has been deposited in China Center for Type Culture Collection CCTCC, Accession No. CCTCC NO: M 2014144. A 5L fermenter, strains of the present invention is a fermented epothilone titers have original strain 2.37mg / L raised to 315.95mg / L, compared to the original starting strain was increased by 132 times, the fermentation epothilone b there starting titer of bacteria 1.02mg / L raised to 290.37mg / L, compared to the original strain departure increased 283-fold. The strain of the invention in full compliance with the industrialized production of epothilone technical specifications, can be used for industrial fermentation production, scientific research has significant social and economic value. CCTCCNO: M2014144 20140423