СРАВНИТЕЛЬНАЯ ХАРАКТЕРИСТИКА ПРОДУКЦИИ ММР-9 и TIMP-1 РАЗЛИЧНЫМИ ПОДТИПАМИ МАКРОФАГОВ

The paper presents a comparative characterization of the MMP-9 and TIMP-1 production by various subsets of macrophages (Mφ) differentiated in the presence of GM-CSF and polarized into M1, M2a and M2c cells. It was shown that all the studied Mφ subtypes produced both MMP-9 and TIMP-1. At the same time, the MMP-9 / TIMP-1 ratio was signifi cantly higher in M2c Mφ compared to M1 and M2a, which may indicate the important role of M2c macrophages during tissue remodeling and restriction of fibrosis.