303 Metabolic Syndrome and Early-Onset of Coronary Artery Disease

Subsequent studies have shown that metabolic syndrome (MetS) defined using the Adult Treatment Panel III (ATP-III) imparts an increased risk of type 2 diabetes mellitus as well as clinical and subclinical coronary artery disease (CAD) in older populations. Because the prevalence of MetS is increasing alarmingly among adolescents and young adults, it is important to quantify its relation with clinical CAD occurring early in life. Aim We sought to examine the association between MetS and early-onset CAD. Methods Between January 2006 and January 2008 we performed a case-control study with 40 early-onset CAD subjects (acute myocardial infarction, angina with ≥ 50% stenosis, or coronary revascularization) in men under age 46 years or women under age 56 years and 60 control subjects matched for gender and age. Results The population was composed by 44 men, median age was 41 years. Different components of Mets were compared for both cases (40 subjects) and control (60 subjects). Blood systolic and diastolic pressure were respectively 129 ± 24 mmHg vs 124 ± 23 mmHg and 76.1 ± 11.4 vs 74.4 ± 12.8 mmHg (p=0.5). Waist circumference was lower in controls with 92 ± 15 cm vs 100.6 ± 12 cm for the cases (p=0.05). HDL cholesterol tend to be higher in controls with 1.19 ± 0.4 mmol/l vs 1.06 ± 0.8 mmol/l (p=0.4). Triglyceride and fasting glycemia were significantly higher in cases with respectively 2.3 ± 1.5 vs 1.34 ± 0.8 mmol/l, and 9.7± 6 vs 6.5 ± 3.4 mmol/l (p ≤ 0.05). Mets was consequently higher in cases, actually 66.7% of the cases had Mets vs 25.7% in controls. (p  Conclusions Presence of MetS was higher in young patients with CAD, a better physical activity and dietary patterns are necessary to prevent this syndrome as it's related to high coronary risk.