Breaking the Silos of Protein Synthesis
2017
Protein synthesis requires factors that are proposed to enhance discrete steps. Eukaryotic initiation factor eIF5A was initially thought to affect initiation; however, it was later shown to facilitate translation elongation at polyproline. Recent work by Schuller et al . demonstrates that eIF5A facilitates both general elongation and termination in yeast, challenging these steps as silos.
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