SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2

SLAP is an adaptor protein that negatively regulates receptor signalling, but its involvement in cancer has not been described. In this study, Naudin et al. demonstrate that SLAP negatively regulates the receptor EphA2 in a Src-dependent manner and is reduced in expression in colorectal cancer.