Integrative modeling of gene expression and metabolism with E-CELL System

A gene-expression model for an E-CELL simulation was constructed, and the simulation was carried out. The model was integrated with a metabolism model of the self-sustaining virtual cell model which was constructed based on aMycoplasma genitalium cell. Details of the model structure and the results of the simulation are shown. AnEscherichia coli lac-operon model was also constructed by integrating and abstracting the gene-expression model. Wherever possible, experimental parameters were used to construct the model