Intrauterine extra-amniotic administration of prostaglandin F2α for therapeutic abortion

Abstract A method of administering prostaglandin F 2α (PGF 2α ) solutions at various intrauterine extra-amniotic sites to induce abortion and to study the effect of PGF 2α on the myometrium is described. Three observations were noted during the study of 7 women between 8 and 20 weeks' gestation: (1) Injection of PGF 2α in the fundus resulted in a greater myometrial response when compared to the response elicited by the same dose injected at lower uterine sites; (2) the sensitivity of the myometrium to PGE 2α appeared to be greater in early pregnancies as compared to later pregnancies; (3) the myometrium responded to PGF 2α by increasing the basal tonus more in early pregnancy than it did in later pregnancies.