5-HT release from platelets and activation of 5-HT2B play a crucial role for development of fibrosis in systemic sclerosis

Systemic sclerosis (SSc) is characterised by progressive vascular disease and organ fibrosis. Tryptophanhydroxylase-1 (tph-1) is the rate-limiting enzyme for the synthesis of 5-hydroxytryptamine (5-HT). After synthesis, 5-HT is stored in large amounts within platelets and can be released upon activation. The aim of the present study was to investigate the role of 5-HT release upon platelet activation and whether 5-HT signalling is involved in the pathogenesis of SSc. Dermal fibroblasts from SSc patients and …