Total synthesis of proinflammatory dihydro-12-KETE metabolites

Abstract The first total synthesis of the 10,11-dihydro-12- k eto e icosa t etra e noic acid (10,11-dihydro-12-KETE) 5 , a proinflammatory metabolite of 12-KETE is reported. In addition, the total synthesis of two other potential metabolites of 12-KETE, namely 8,11-dihydro-12-KETE 6 and 8,9-dihydro-12-KETE 7 , is also described. These three synthetic compounds are aimed at investigating a new biosynthetic reductive pathway for 12- h ydroxy e icosa t etra e noic acid (12-HETE) and 12-KETE.