Effect of Δ9-tetrahydrocannabinol on immobilization-induced changes in rat adrenal medullary enzymes

Abstract The effect of Δ 9 -tetrahydrocannabinol on adrenal medullary catecholamine-forming enzymes in immobilized and non-immobilized control rats was studied. The immobilization-induced increase in tyrosine hydroxylase and dopamine-β-hydroxylase was markedly enhanced by Δ 9 -tetrahydrocannabinol; however, neither ethanol alone nor ethanol in combination with Δ 9 -tetrahydrocannabinol altered the levels of the enzymes in non-immobilized control rats.