Relationship of MIMECAN gene, cell nuclear factor-κB and interleukin-24 with endometrial cancer

Objective To explore the expression of MIMECAN gene, cell nuclear factor(NF)-κB, interleukin(IL)-24 and their relationship with endometrial carcinoma. Methods From January 2008 to January 2013, a total of 120 hospitalized patients with endometrial carcinoma in Huai'an Affiliated Hospital of Xuzhou Medical College were included in the study as research group(n=120), they were further divided into stageⅠ subgroup(n=45), stageⅡsubgroup (n=30), stage Ⅲsubgroup (n=24) and stage Ⅳ subgroup (n=21) according to the International Federation of Gynecology and Obstetrics(FIGO) pathological stages.Meanwhile, another 40 healthy women were chosen as control group(n=40). The expression of MIMECAN gene, NF-κB, IL-24 levels were detected by enzyme-linked immunosorbent assay(ELISA). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Affiliated Hospital of Xuzhou Medical College.Informed consent was obtained from each participants. Results ①The levels of MIMECAN gene, NF-κB, IL-24 in research group were obviously higher than those of control group, and the differences were significant(P<0.05). There also were significant differences among four subgroups in levels of MIMECAN gene, NF-κB, IL-24(P<0.05). ②There were positive correlation between levels of MIMECAN gene, NF-κB, IL-24 and the severity of endometrial carcinoma(r=0.69, 0.73, 0.82; P<0.05). ③The NF-κB was positively correlated with MIMECAN gene and IL-24 in research group(r=0.76, 0.78; P<0.05). Conclusions MIMECAN gene, NF-κB, IL-24 interaction might promote the development of endometrial carcinoma. Key words: MIMECAN gene; Cell nuclear factor κB; Interleukin 24; Endometrial carcinoma