Prospective Evaluation of 1-day Polyethylene Glycol-3350 Bowel Preparation Regimen in Children

Objectives: The aim of the present study was to evaluate efficacy, safety, and tolerability of a pediatric colonoscopy bowel preparation regimen composed of polyethylene glycol-3350 (PEG-3350) and a sports drink completed in a few hours. Methods: A prospective, open-label trial of a colonoscopy bowel preparation in children ages 8 to 18 years that included 238g of PEG3350 mixed with 1.9 L of Gatorade completed in a few hours. Efficacy was determined using the Boston Bowel Preparation Scale. Basic metabolic profiles and questionnaires were obtained that assessed for safety, adverse effects, tolerability, and patient acceptability. Results: Forty-six patients completed the study. Patients were predominately boys (56.5%) with a mean age of 14.50 years (SD � 2.9 years). Forty-three (93.5%) were able to complete the regimen. All of the colonoscopies were completed to the cecum and 84% had terminal ileum visualization. Seventy-seven percent were found to be effective preparations. Nausea/vomiting were the most common reported adverse effect (60%) followed by abdominal pain/cramping (44%) and fatigue/ weakness (40%). Overall, the regimen was acceptable with 1 exception being the large volume to drink. There were no clinically significant changes in basic metabolic profiles, although there was a statistically significant decrease in the mean potassium (0.16 mEq/L; P ¼0.016), blood urea nitrogen (2.68 mg/dL; P <0.0001), and carbon dioxide (1.89 mmol/L; P <0.0001). Conclusions: This study demonstrated that PEG-3350 þGatorade administered in a few hours is an effective, safe, and moderately tolerable bowel preparation regimen for colonoscopy in children.