The effect of C-terminal fragment of ANF-ANF(24–28)OH on the cardiovascular system in rat

Abstract 1. The effect of C-terminal fragment of ANF-ANF(24–28)OH on the cardiovascular system was investigated in rats 2. In vivo this pentapeptide caused the fall of systolic and diastolic blood pressure. 3. ANF(24–28)OH increased cardiac contraction amplitude and changed coronary outflow in vitro . 4. These experiments showed that the shorter fragment of ANF containing five amino acids: Asn24-Ser25-Phe26-Arg27-Tyr28-COOH is a bioactive substance.