A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response.

Kelli A. Connolly,Manik Kuchroo,Aarthi Venkat,Achia Khatun,Jiawei Wang,Ivana William,Noah I. Hornick,Brittany Fitzgerald,Martina Damo,Moujtaba Y Kasmani,Can Cui,Eric Fagerberg,Isabel Monroy,Amanda Hutchins,Julie F. Cheung,Gena G. Foster,Dylan L Mariuzza,Mursal Nader,Hongyu Zhao,Weiguo Cui,Smita Krishnaswamy,Nikhil S. Joshi

A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response.

2021

“Stem-like” TCF1+ CD8+ T cells (TSL) are necessary for long-term maintenance of T cell responses and the efficacy of immunotherapy but, as tumors contain signals that should drive T-cell terminal-d...

Keywords:

Immunotherapy
Cytotoxic T cell
Immune system
T cell
Cancer research
Text mining
Lymph node
CD8
Biology

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