The research progress of the role of myeloperoxidase in the pathogenesis of hypertension

Myeloperoxidase (MPO) is an enzyme that links inflammatory response and oxidative stress. It catalyzes the oxidation reaction, produces a large amount of cytotoxic reactive oxygen species(ROS), reduces the bioavailability of nitric oxide, impairs endothelial function. MPO participates the target organs damage of hypertension, such as heart, brain and kidney. In addition, many studies have shown that genetic polymorphisms of MPO is associated with the risk of cardiovascular disease. This article reviews the research progress of the role of MPO in the pathogenesis of hypertension. Key words: Hypertension; Myeloperoxidase