The effect of a clover extract on the proliferation of human and murine lymphocytes in vitro

: The extracts were prepared from meadow clover harvested at the stages of blossoming and budding. The major biological activity of such extracts is represented by flavonoid compounds. The influence of extracts on the proliferation of peripheral blood mononuclear cells obtained from healthy donors and of inbred mouse splenocytes in vitro was analyzed. Both preparations stimulated cellular proliferation. The lever of stimulating activity correlated with the stage-dependent concentration of flavonoids.