A solid phase approach to PDMP analogs: A general strategy for combinatorial library

Abstract The present work reports the first solid phase synthesis of biologically interesting d - threo -1-phenyl-2-decanoylamino-3-morpholino-1-propanol ( d - threo -PDMP) derivatives. This synthetic strategy includes facile preparation of versatile azido intermediate ( 5 ) in a relatively short sequence and the subsequent derivatization of 5 , which led to a series of sulfonamide, urea and heterocycle substituted PDMP analogs ( 10 and 10 ′). With this method, a 5280-member compound library has been successfully built by IRORI Nanokan © system.